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FKBP12 (FKBP1A)
英文名：Rabbit Monoclonal Antibody
Cas號(hào)：
Cas號(hào)：
檢測(cè)信息查詢
| 貨號(hào) | 規(guī)格 | 貨期 | 庫(kù)存 | 價(jià)格 | 促銷價(jià) | 訂購(gòu) |
| 1308113591-100ul | 現(xiàn)貨 | 0 | ￥0 |
| 別 名 | FKBP1A antibody, FKBP-12 antibody, FKBP1 antibody, FKBP12 antibody, PKC12 antibody, PKCI2 antibody, PPIASE antibody, Peptidyl-prolyl cis-trans isomerase FKBP1A antibody, Immunophilin FKBP12 antibody, Rotamase antibody |
| Cas號(hào) | |
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| 產(chǎn)品參數(shù) | 【產(chǎn)品介紹】FKBP12 (Fkbp1a) is a member of the
FK-506-binding protein (FKBP) family. This family of proteins possesses peptidyl-prolyl cis-trans isomerase (PPIase) activity and is believed to play an important role in accelerating the rate at which proteins fold into their native conformations (1). FKBP12 was originally identified as a cytosolic receptor for the immunosuppressant drugs, FK506 and rapamycin, and later shown to be involved in cell-cycle regulation and in intracellular calcium homeostasis. Binding of FKBP12 to rapamycin through its FK506/rapamycin-binding/ PPIase domain mediates the immunosuppressive and anti-tumor effects of rapamycin, a drug that has shown to arrest tumor cells in G1 phase of the cell cycle and to reduce tumor angiogenesis (2). FKBP12 is highly conserved from yeast through human and is relatively abundant in most tissues and cell types (3). Recommended Applications WB, ICC Applications and Recommended Dilution Factors WB: 1:10,000 - 50,000 ICC: 1:50 - 100 Species Reactivity Human, Mouse, Rat Products Data Western blot analysis on (A) fetal brain, (B) U937 and (C) SH-SY5Y cell lysates using anti-FKBP12 RabMAb (cat. #2832-1). Specificity A synthetic peptide corresponding to residues at the C-terminus in human FKBP12 was used as an immunogen. |
| 性狀 | 【反應(yīng)特異性】Human , Mouse , Rat
【克隆 ID】EPR3888 【用途】WB , ICC 【抗原分子量】12kDa |
| 貯存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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