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Fc gamma RIIb/CD32 Phospho (pY292) (FCGR2B)
英文名：Rabbit Monoclonal Antibody
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檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308113580-100ul | 現貨 | 0 | ￥0 |
| 別 名 | FCGR2B antibody, CD32 antibody, CD32B antibody, FCG2 antibody, FCGR2 antibody, IGFR2 antibody, Low affinity immunoglobulin gamma Fc region receptor II-b antibody, CDw32 antibody, Fc-gamma RII-b antibody |
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| 產品參數 | 【產品介紹】Low affinity IgG Fc receptor gamma II
(Fc-gamma II), also known as CD32, is a member of the immunoreceptor tyrosine-based activating/ inhibitory motif (ITAM/ITIM) family. Fc gamma receptors play a critical role in immunity by linking the IgG antibody mediated response with the regulatory functions of the immune system (1). Three classes of Fc gamma receptor exist; Fc gamma RI (CD64, a high affinity receptor), Fc gamma RII, and RIII (CD32 and CD16 respectively, both low affinity receptors). Fc gamma RIIa is an activating receptor, while RIIb1, RIIb2, and RIIb3 are inhibitory receptors generated by alternative splicing (1-2). Fc gamma RIIa is critical for antigen-presenting-cell activation and Fc gamma RIIb downregulates B-cell functions (3). Coligation of FcgammaRIIb with the B-cell antigen receptor (BCR) results in the abrogation of B-cell activation and become phosphorlyated by protein tyrosine kinase (PTK) (4) Recommended Applications WB, IP Applications and Recommended Dilution Factors WB: 1:50,000 - 100,000 IP: 1:70 Species Reactivity * Human, Mouse *Cross reactivity determined by western blot only, mouse reactivity predicted based on sequence analysis Products Data A. Western blot analysis on Daudi cell lysates using anti-Phospho-Fc gamma RIIb (py292) RabMAb (cat. #2308-1), 1:100,000 dilution. Cells were either (A) untreated (B) treated with pervanadate. Specificity A phospho specific peptide corresponding to residues surrounding tyrosine 292 of human Fc gamma RIIb. This antibody detects Fc gamma RIIb phosphorylated on tyrosine 292. |
| 性狀 | 【反應特異性】Human , Mouse
【克隆 ID】EP926Y 【用途】WB , IP 【抗原分子量】40/44kDa |
| 貯存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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