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CaMKII Phospho (pT286) (CAMK2A)
英文名：Rabbit Monoclonal Antibody
Cas號：
Cas號：
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| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308113392-100ul | 現貨 | 0 | ￥0 |
| 別 名 | CAMK2A antibody, CAMKA antibody, KIAA0968 antibody, Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody, antibody |
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| 產品參數 | 【產品介紹】Calcium/calmodulin-dependent protein kinase
II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. It is a ubiquitous serine/threonine protein kinase which is abundant in brain as a major PSD constituent. This enzyme is composed of distinct but related subunits (alpha, beta, gamma, and delta) (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2). The most important autophosphorylation site is Threonine 286, which resides in the vicinity of the autoinhibitory domain (3). Recommended Applications WB Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 Species Reactivity * Human, Mouse, Rat *Species cross-reactivity is based on WB analysis Products Data Western blot analysis on rat brain lysates using anti-Phospho-CaMKII (pT286) RabMAb (cat. #3891-1). Cells were either (A) untreated (B) treated with Lambda Phosphatase. Specificity A phospho specific peptide corresponding to residues surrounding Threonine 286 of human CaMKII was used as an immunogen. This antibody only detects CaMKII phosphorylated at Threonine 286. |
| 性狀 | 【反應特異性】Human , Mouse , Rat
【克隆 ID】EPR1830 【用途】WB 【抗原分子量】45 - 70kDa |
| 貯存 | Storage Condition and Buffer Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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