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LFA-β2/ITGB2
英文名：LFA-β2/ITGB2
Cas號：
Cas號：
檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308114493-100ul | 現貨 | 0 | ￥0 |
| 別 名 | Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta, Complement recept o r C3 subunit beta, CD18 antigen |
| Cas號 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 產品參數 | 【產品介紹】In the immune system, integrins have
essential roles in leukocyte trafficking a n d function. These include immune cell attachment to endothelial a n d antigen-presenting cells, cytotoxicity, a n d extravasation into tissues (1). Integrin adhesion recept o r s transduce signals that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation a n d survival. Their intracellular domain has no catalytic function, indicating that interaction with other transducing molecules is crucial f o r integrin- mediated signaling. JAB1 (Jun activation domain- binding protein 1), a coactivat o r of the c-Jun transcription fact o r , has been identified as a protein that interacts with the cytoplasmic domain of the beta2 subunit of the alphaL/beta2 integrin LFA-1 (2). Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer f o r mation a n d n o r mal cell surface expression of these recept o r s, leading to life-threatening bacterial infections (3) WB: 1:2000 IP: 1:50 A. Western blot analysis on K562 cell lysate using anti-LFA-β2 RabMAb (cat. # 1890-1), dilution 1:2000. |
| 性狀 | 【產品類型】Rabbit Monoclonal IgG
【反應特異性】Human 【克隆 ID】EP1286Y 【用途】WB , IP 【產品性狀】 【陽性對照】 【產品濃度】 【細胞定位】 【抗原分子量】95 kDa |
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