小程序掃碼下單
本網站銷售的所有產品僅用于工業應用或者科學研究等非醫療目的，不可用于人類或動物的臨床診斷或者治療，非藥用，非食用。
JAK3
英文名：JAK3
Cas號：
Cas號：
檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308114468-100ul | 現貨 | 0 | ￥0 |
| 別 名 | JAK3 antibody, JAK-3 antibody, JAK3_HUMAN antibody, JAKL antibody, L-JAK antibody, LJAK antibody, Tyrosine-protein kinase JAK3 antibody, Leukocyte janus kinase antibody |
| Cas號 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 產品參數 | 【產品介紹】JAK3 is a member of the Janus family
(JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. The JAK family is constitutively associated with cytokine receptors; upon binding to the receptor, the cytokine becomes phosphorylated (1). JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1). JAK3 is unique among JAK family members because it serves a function in normal lymphocyte development. In addition, JAK3 is the only one that interacts with the common gamma chain of the following Interleukin receptors: IL-2, IL-4, IL-7, IL-9, and IL-15 receptors (3). Loss of JAK3 function causes a severe block in T-cell and natural killer (NK) cell development (4). Defects in JAK3 are a cause of severe combined immunodeficiency (SCID), characterized by an absence of T-cell-mediated cellular immunity (5). Recommended Applications WB, ICC Applications and Recommended Dilution Factors WB: 1:1,000-10,000 ICC: 1:250 - 500 Species Reactivity Human Products Data Western blot analysis on (A) IM-9 and (B) TF-1 cell lysates using anti-JAK3 RabMAb (cat. # 2856-1). Specificity A synthetic peptide corresponding to residues on the N-terminus in human JAK3 was used as an immunogen. |
| 性狀 | 【產品類型】Rabbit Monoclonal Antibody
【反應特異性】Human 【克隆 ID】EPR908(2) 【用途】WB , ICC 【產品性狀】 【陽性對照】 【產品濃度】 【細胞定位】 【抗原分子量】115kDa |
| 貯存 | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
滬公網安備 31012002003054號