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JAK3
英文名：JAK3
Cas號：
Cas號：
檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308114466-100ul | 現貨 | 0 | ￥0 |
| 別 名 | Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK |
| Cas號 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 產品參數 | 【產品介紹】Jak3 is a member of the Janus family
tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines a n d interferons. Jaks associate with cytokine recept o r s; upon lig a n d binding, Jaks phosph o r ylate the recept o r . The phosph o r ylated recept o r s are bound by SH2-containing proteins, one class of which is the signal transducers a n d activat o r s of transcription (STATs). Activated STATs translocate to the nucleus to mediate gene transcription (1, 2). Jak3 is activated after binding to the gamma chain of Interleukin recept o r s, specifically IL-2, IL-4, IL-7, IL-9, a n d IL-15 recept o r s. Jak3 has been implicated in mast cell-mediated immediate hypersensitivity reactions, autoimmune dis o r ders, a n d acute lymphoblastic leukemia. Jak3 inhibit o r has shown clinical potential as a new class of immunomodulat o r y agents with anti-leukemic a n d immunosuppressive properties (3). WB: 1:2000 A. Western blot using anti-Jak3 Rabbit Polyclonal (cat. # 1752-1) on TF-1 cell lysate at 1:2000 dilution. |
| 性狀 | 【產品類型】Rabbit Polyclonal IgG Affinity Purified
【反應特異性】Human , Rat 【克隆 ID】Polyclonal 【用途】WB 【產品性狀】 【陽性對照】 【產品濃度】 【細胞定位】 【抗原分子量】115 kDa |
| 貯存 |
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