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FAK Phospho (pY576/577) (PTK2)
英文名：Rabbit Monoclonal Antibody
Cas號：
Cas號：
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| 貨號 | 規(guī)格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308113575-100ul | 現(xiàn)貨 | 0 | ￥0 |
| 別 名 | PTK2 antibody, FADK antibody, FAK antibody, FAK1 antibody, FRNK antibody, pp125FAK antibody, Focal adhesion kinase 1 antibody, Protein-tyrosine kinase 2 antibody, pp125FAK antibody |
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| 產(chǎn)品參數(shù) | 【產(chǎn)品介紹】Focal adhesion kinase (FAK) is a
non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis (1). FAK is composed of a central catalytic domain flanked by large N- and C-terminal regions. FAK is activated by phosphorylation at tyrosine 397 in response to integrin clustering which can be induced by cell adhesion or antibody cross-linking or via G-protein-coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid (2-3). Phosphorylation of FAK Tyr-397 creates a binding site for Src-family kinases, and phosphorylation of FAK Tyr-576/Tyr-577 in the kinase domain activation loop enhances catalytic activity (4). Increased FAK expression has been correlated with the enhanced motility and invasiveness of human tumor cells, as well as with promoting increased cell proliferation (5). Recommended Applications WB, ICC, IP, FC Applications and Recommended Dilution Factors WB: 1:10,000 - 50,000 ICC: 1:50 - 100 IP: 1:40 FC: 1:20 Species Reactivity * Human, Mouse *Cross reactivity determined by western blot only. Products Data A. Western blot analysis on NIH-3T3 cell lysates using anti-Phospho-FAK1 (pY576/577) RabMAb (cat. #2183-1), 1:50.000 dilution. Cells were either (A) untreated (B) treated with pervanadate. Specificity A phospho-specific peptide corresponding to residues surrounding Tyrosine 576/577 of human FAK was used as an immunogen. This antibody detects FAK phosphorylated at Y576/577. |
| 性狀 | 【反應(yīng)特異性】Human , Mouse
【克隆 ID】EP1832Y 【用途】WB , ICC , FC , IP 【抗原分子量】125kDa |
| 貯存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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