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Recombinant Human Tumor Necrosis Factor alpha, His
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檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308132933-10 μg | 0 | ￥2000 | ||||
| 1308132933-50 μg | 0 | ￥4400 |
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| 性狀 | Recombinant Human Tumor Necrosis Factor alpha, His 是一種帶有標簽的人重組腫瘤壞死因子α (TNF-α)。Recombinant Human Tumor Necrosis Factor alpha 是一種多效性細胞因子，是炎癥的主要介質之一，參與多種傳染病和寄生蟲病。似乎與血腦屏障、炎癥、血栓形成和腦損傷相關的血管變化有關。
Synonyms rHuTNF-α, His; Cachectin; TNFSF2 ; 重組人腫瘤壞死因子 α，His 標簽 Species Human Source E. coli Accession P01375 Gene ID 7124 Molecular Weight Approximately 18.3 kDa AA Sequence MHHHHHHVRS SSRTPSDKPV AHVVANPQAE GQLQWLNRRA NALLANGVEL RDNQLVVPSE GLYLIYSQVL FKGQGCPSTH VLLTHTISRI AVSYQTKVNL LSAIKSPCQR ETPEGAEAKP WYEPIYLGGV FQLEKGDRLS AEINRPDYLD FAESGQVYFG IIAL Biological Activity The ED50 is <0.13 ng/mL as measured by L-929 mouse fibrosarcoma cells, corresponding to a specific activity of >7.69 × 106 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <1.0 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Tumor Necrosis Factor alpha, His (rHuTNF-α, His) to 100 μg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Tumor Necrosis Factor alpha, His (rHuTNF-α, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 4 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine produced by a wide variety of cell types of mostly hematopoietic, but also of nonhematopoietic, origin. TNFα is instrumental in the immune elimination of various infectious agents such as Candida albicans, Listeria monocytogenes, or mycobacteria and exerts potent proinflammatory effects, e.g. by inducing the expression of adhesion molecules such as VCAM-1, intercellular adhesion molecule 1 (ICAM-1), or E-selectin on endothelial cells and other cell types. Aberrant production of TNFα, however, has been also implicated in the pathogenesis of various diseases, such as rheumatoid arthritis, insulin-dependent diabetes-mellitus, sialoadenitis, and inflammatory bowel disease, in particular Crohn's disease[1][2]. |
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