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Recombinant Rat Thrombopoietin, His (CHO-expressed)
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| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308132928-10 μg | 0 | ￥4200 | ||||
| 1308132928-50 μg | 0 | ￥12400 |
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| 性狀 | Recombinant Rat Thrombopoietin, His (CHO-expressed) 是一種在 CHO 細胞中產生的帶有標簽的重組大鼠血小板生成素 (TPO)。Recombinant Rat Thrombopoietin 是巨核細胞生成的主要細胞因子調節因子。
Synonyms rRtThpo, His; C-mpl ligand; MGDF ; 重組大鼠血小板生成素，His 標簽 Species Rat Source CHO Accession P49745 Gene ID 81811 Molecular Weight Approximately 22 kDa AA Sequence SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRGKVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKFHHHHHH Biological Activity The ED50 is <0.2 ng/mL as measured by human MO7e cells, corresponding to a specific activity of >5 × 106 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Rat Thrombopoietin, His (CHO-expressed) (rRtThpo, His) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Rat Thrombopoietin, His (CHO-expressed) (rRtThpo, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Thrombopoietin (TPO) is the master cytokine regulator of megakaryopoiesis. In addition to regulation of megakaryocyte and platelet number, TPO is important for maintaining proper hematopoietic stem cell (HSC) function. TPO produced mainly in the liver, stimulates both megakaryocyte colony formation and enhances megakaryocyte maturation in the bone marrow leading to increased platelet production. TPO binds to its receptor, TPOR/MPL, which is expressed on hematopoietic stem cells (HSCs), megakaryocytes and platelets. Circulating TPO concentrations are controlled by MPL via receptor-mediated internalization and degradation, and in part by sensing of senescent platelets by the Ashwell-Morell receptor in the liver[1]. |
| 貯存 |
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