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Recombinant Human Transforming Growth Factor alpha
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檢測信息查詢
| 貨號 | 規(guī)格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308132927-10 μg | 0 | ￥1400 | ||||
| 1308132927-50 μg | 0 | ￥3200 |
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| 性狀 | Recombinant Human Transforming Growth Factor alpha (TGF-α) 是一種結(jié)合表皮生長因子 (EGF) 受體并刺激細(xì)胞生長的 50 個氨基酸多肽。
Synonyms rHuTGF-α; ETGF; TGF-type I ; 重組人轉(zhuǎn)化生長因子 α Species Human Source E. coli Accession P01135 Gene ID 7039 Molecular Weight Approximately 5.8 kDa AA Sequence VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA Biological Activity The ED50 is <0.2 ng/mL as measured by BALB/c 3T3 cells, corresponding to a specific activity of >5 × 106 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Transforming Growth Factor alpha (rHuTGF-α) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human Transforming Growth Factor alpha (rHuTGF-α) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Transforming growth factor alpha (TGF-α) is a principal molecule in the normal and neoplastic development of the mammary gland. Binding of TGF-α to the epidermal growth factor receptor (EGFR), activates the EGFRs' endogenous tyrosine kinase activity and stimulates growth of the epithelium in the virgin and pregnant mouse mammary gland. TGF-α expression can be detected in breast cancer cells in vivo and in vitro and overexpression can elicit partial transformation or immortalized human and rodent mammary epithelial cells[1][2]. |
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