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Recombinant Human B7-H2/ICOSLG, Fc Chimera (HEK293-expressed)
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| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308132835-10 μg | 0 | ￥2200 | ||||
| 1308132835-50 μg | 0 | ￥4200 |
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| 性狀 | Recombinant Human B7-H2/ICOSLG, Fc Chimera (HEK293-expressed) 是 HEK293 細胞中產生的 C-末端含人 IgG1 Fc 片段的多肽鏈。ICOSLG 屬于共刺激分子 B7 家族。
Synonyms rHuB7-H2/ICOSLG, Fc Chimera; B7 homolog 2; B7RP-1; CD275 Species Human Source HEK 293 Accession O75144 Gene ID 23308 Molecular Weight 70-80 kDa AA Sequence DTQEKEVRAM VGSDVELSCA CPEGSRFDLN DVYVYWQTSE SKTVVTYHIP QNSSLENVDS RYRNRALMSP AGMLRGDFSL RLFNVTPQDE QKFHCLVLSQ SLGFQEVLSV EVTLHVAANF SVPVVSAPHS PSQDELTFTC TSINGYPRPN VYWINKTDNS LLDQALQNDT VFLNMRGLYD VVSVLRIART PSVNIGCCIE NVLLQQNLTV GSQTGNDIGE RDKITENPVS TGEKNAATWS Biological Activity 5 μg/mL (100 μL/well) of immoblized recombinant human B7-H2/ICOSLG-Fc can bind human Biotin-B7-H2/ICOSLG-Fc with a linear range of 0.76-12.21 μg/mL. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS, 5% trehalose and mannitol. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human B7-H2/ICOSLG, Fc Chimera (HEK293-expressed) (rHuB7-H2/ICOSLG, Fc Chimera) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human B7-H2/ICOSLG, Fc Chimera (HEK293-expressed) (rHuB7-H2/ICOSLG, Fc Chimera) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background As a member of the B7 family, inducible co-stimulator ligand (ICOSLG) expressed on tumor cell has been reported to have an important role in tumor immunity. As the counter ligand of ICOS, a CD28-related molecule, ICOSLG is expressed on professional antigen-presenting cell (APCs; such as dendritic cells (DCs) and B cells) and on some tumor cells (such as glioma cells and gastric carcinoma cells). ICOSLG is the only B7 family member that preferentially co-stimulates type 2T helper cell (Th2) responses, and interestingly, this unique molecule has a critical role in antitumor immunity. ICOSLG expression on solid tumors (implanted-transfected tumors) aids in both NK mediated and CD8+ cytotoxic T cell (CTL) activation and killing. Several studies using ICOSLG-transfected solid tumor cell lines found that ICOSLG induced CD8+ cytotoxic lymphocyte-mediated tumor regression[1]. |
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