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IkappaB-alpha Phospho (S32) (NFKBIA)
英文名：IkappaB-alpha Phospho (S32) (NFKBIA)
Cas號：
Cas號：
檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308114436-100ul | 現貨 | 0 | ￥0 |
| 別 名 | NFKBIA antibody, IKBA antibody, MAD-3 antibody, NFKBI antibody, NF-kappa-B inhibitor alpha antibody, Major histocompatibility complex enhancer-binding protein MAD3 antibody |
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| 產品參數 | 【產品介紹】The NF-kappaB/Rel transcription factors
are present in the cytosol in an inactive state, complexed with the inhibitory IkappaB-alpha protein (1-5). In response to many different NF-kappaB- inducing agents including T-cell mitogens, proinflammatory cytokines, and viral transactivators, the inhibitory IkappaB-alpha is rapidly phosphorylated and degraded (2). Phosphorylation of IkappaB-alpha at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin and subsequent degradation of IkappaB-alpha (3). Activation of NF-kappaB can also be achieved after tyrosine phosphorylation of IkappaBalpha at tyrosine 42, an event that also ultimately leads to the dissociation of NF-kappaB and IkappaBalpha (4). Phosphorylation of IkappaB-alpha at Ser32 and Tyr42 is critical for activation of NF-kappaB, which then translocates to the nucleus and induces transcription of genes that protect organism (1-5). Recommended Applications WB, ICC, IP Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 ICC: 1:50 - 100 IP: 1:10 - 100 Species Reactivity Human Products Data Western blot analysis on Hela cell lysates using anti-Phospho-IkappaB-alpha (pS32) RabMAb (cat. #2798-1). Cells were either (A) untreated (B) treated with Calyculin A and TNF-a Specificity A phospho specific peptide corresponding to residues surrounding Serine 32 of human IkappaB-alpha was used as an immunogen. |
| 性狀 | 【產品類型】Rabbit Monoclonal Antibody
【反應特異性】Human 【克隆 ID】EPR3148 【用途】WB , ICC , IP 【產品性狀】 【陽性對照】 【產品濃度】 【細胞定位】 【抗原分子量】40kDa |
| 貯存 | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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