小程序掃碼下單
本網站銷售的所有產品僅用于工業應用或者科學研究等非醫療目的，不可用于人類或動物的臨床診斷或者治療，非藥用，非食用。
HSD17B1 (C-term)
英文名：HSD17B1 (C-term)
Cas號：
Cas號：
檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308114417-100ul | 現貨 | 0 | ￥0 |
| 別 名 | HSD17B1 antibody, EDH17B2 antibody, EDHB17 antibody, HSD17 antibody, MGC138140 antibody, SDR28C1 antibody, Estradiol 17-beta-dehydrogenase 1 antibody, E2DH antibody, Placental 17-beta-hydroxysteroid dehydrogenase antibody |
| Cas號 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 產品參數 | 【產品介紹】The principal human estrogen, 17 beta-
estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4) Recommended Applications WB, IHC, ICC, FC Applications and Recommended Dilution Factors WB: 1:500 IHC: 1: 100 - 250 ICC: 1:50 FC: 1:40 Species Reactivity * Human *Cross reactivity determined by western blot only. Products Data A. Western blot analysis on human placenta lysate using anti-HSD17B1 RabMAb (cat. # 2127-1), dilution 1:500. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-HSD17B1 RabMAb (cat.# 2127-1). Specificity A synthetic peptide corresponding to residues on the C-terminus of human HSD17B1 was used as an immunogen. |
| 性狀 | 【產品類型】Rabbit Monoclonal Antibody
【反應特異性】Human 【克隆 ID】EP1681Y 【用途】WB , IHC , ICC , FC 【產品性狀】 【陽性對照】 【產品濃度】 【細胞定位】 【抗原分子量】35kDa |
| 貯存 | Store at -20 °C. 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
滬公網安備 31012002003054號