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Alpha-Actinin 3
英文名：Alpha-Actinin 3
Cas號：
Cas號：
檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308114370-100ul | 現貨 | 0 | ￥3575 |
| 別 名 | Alpha-actinin skeletal muscle isof o r m 3, F-actin cross-linking protein |
| Cas號 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 產品參數 | 【產品介紹】The alpha-actinins are a multigene family
of four actin-binding proteins related to dystrophin. The two skeletal muscle isof o r ms of alpha-actinin (ACTN2 a n d ACTN3) are maj o r structural components of the Z-line involved in anch o r ing the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibers. Absence of alpha-actinin-3 is not associated with an obvious disease phenotype, raising the possibility that ACTN3 is functionally redundant in humans, a n d that alpha-actinin-2 is able to compensate f o r alpha-actinin-3 deficiency (1). Alpha-Actinin-3 is specifically expressed in fast-twitch myofibers responsible f o r generating f o r ce at high velocity. The absence of a disease phenotype secondary to alpha-actinin-3 deficiency is likely due to compensation by the homologous protein, alpha-actinin-2. However, the high degree of evolutionary conservation of ACTN3 suggests function(s) independent of ACTN2. Highly significant associations between ACTN3 genotype a n d athletic perf o r mance have been demonstrated in both male a n d female athletes. Specificity: A synthetic peptide c o r responding to residues on the N-terminus of human alpha-actinin 3 was used as an immunogen. Recommended Applications WB, IHC, ICC, FC Applications and Recommended Dilution Factors WB: 1:5,000-10,000 IHC: 1:100 - 250 ICC: 1:100 - 250 FC: 1:200 Species Reactivity * Human, Mouse, Rat * Products Data Western blot analysis on human skeletal muscle lysate using anti-alpha-actinin 3 RabMAb (cat. # 2316-1), dilution 1:10,000. Immunohistochemical analysis of paraffin-embedded human muscles using anti-Alpha-Actinin-3 RabMAb (cat. #2316-1). Specificity A synthetic peptide corresponding to residues on the N-terminus of human alpha-actinin 3 was used as an immunogen. |
| 性狀 | 【產品類型】Rabbit Monoclonal IgG
【反應特異性】Human , Mouse , Rat 【克隆 ID】EP2531Y 【用途】WB , IHC , FC , IP 【產品性狀】 【陽性對照】 【產品濃度】 【細胞定位】 【抗原分子量】100 kDa |
| 貯存 | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months. |
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