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EphA3 Phospho (pY779) / EphA4 (pY779) / EphA5 (pY833) (EPHA3)
英文名：Rabbit Monoclonal Antibody
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檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308113552-100ul | 現貨 | 0 | ￥0 |
| 別 名 | EPHA3 antibody, EK4 antibody, ETK antibody, ETK1 antibody, HEK antibody, HEK4 antibody, TYRO4 antibody, Ephrin type-A receptor 3 antibody, HEK antibody, Tyrosine-protein kinase TYRO4 antibody, Tyrosine-protein kinase receptor ETK1 antibody |
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| 產品參數 | 【產品介紹】Ephrin receptor tyrosine kinases (RTKs)
and their ligands (ephrins) are highly conserved families that mediate cell movement during development (1). There are 14 known receptors, classed into either EphA or EphB, and 8 known ligands, classed into ephrin A or ephrin B. EphA receptors preferably interacts with glycosylphosphatidylinositol-linked ephrins (ephrin A), while EphB receptors preferably interacts with transmembrane ligands (ephrin B) (2). Multiple ligands are specific to each Ephrin receptors and cause receptor activation through transphosphorylation (3, 4). Both receptor and ligand-initiated signals can regulate repulsion, adhesion and de-adhesion mechanisms for the motility of adherent cells (5). Ephrin A3 (EphA3, Mek4, Hek, Hek4) binds to ephrin-A1 to A5 and ephrin-B1. A mutation in EphA3 has been linked to pathogenesis in several tumors, such as breast, lung, and pancreatic cancers (6). Tyrosine 779 of EphA3 is phosphorylated and required to mediate cell de-adhesion upon ephrin-A5 stimulation (7). Recommended Applications WB Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 Species Reactivity * Human, Mouse, Rat *Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on HeLa cell lysates using anti-Phospho-EphA3 (pY779) / EphA4 (pY779) / EphA5 (pY833) RabMAb (cat. #5252-1). Cells were either (A) untreated or (B) treated with Pervanadate. Specificity A phospho specific peptide corresponding to residues surrounding Tyrosine 779 of human EphA3, Tyrosine 779 of EphA4, and Tyrosine 833 of EphA5 was used as an immunogen. This antibody only detects EphA3 phosphorylated at Tyrosine 779, EphA4 phosphorylated at Tyrosine 779, and EphA5 phosphorylated at Tyrosine 833. |
| 性狀 | 【反應特異性】Human , Mouse , Rat
【克隆 ID】EPR5684 【用途】WB 【抗原分子量】133kDa |
| 貯存 | Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt |
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