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Recombinant Human Insulin-like growth factor-binding protein 4, His (HEK-expressed)
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| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308132881-10 μg | 0 | ￥3800 | ||||
| 1308132881-50 μg | 0 | ￥9800 |
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| 性狀 | Recombinant Human Insulin-like growth factor-binding protein 4, His (HEK-expressed) 為胰島素樣生長因子結合蛋白家族一員，與胰島素樣生長因子 (IGF) 結合，介導 IGF 非依賴性生物活動。
Synonyms rHuIGF-BP-4, His; IBP-4; IGFBP-4; BP4 ; 重組人胰島素樣生長因子結合蛋白 4 His (HEK 細胞表達) Species Human Source HEK 293 Accession P22692 Gene ID 3487 Molecular Weight 30-35 kDa AA Sequence DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFREHHH HHH Biological Activity The ED50 is <50 ng/mL as measured by FDC-P1 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Insulin-like growth factor-binding protein 4, His (HEK-expressed) (rHuIGF-BP-4, His) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human Insulin-like growth factor-binding protein 4, His (HEK-expressed) (rHuIGF-BP-4, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background The insulin-like growth factor-binding protein (IGFBP) family consists of six different protein members (IGFBP1-6) that show high inhibition for IGF-1 and IGF-2. IGFBP-4 is a smallest member and modulates the biologic functions by binding to IGFs. Moreover, IGFBP-4 mediates IGF-independent biologic activities. IGFBP-4 inhibits colorectal cancer, breast cancer and glioblastoma cells growth. IGFBP-4 acts a crucial inflammatory mediator in the occurrence of severities acute respiratory distress syndrome, which is responsible for cancer proliferation, migration and apoptosis[1]. |
| 貯存 |
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- Recombinant Human Insulin-like growth factor-binding protein 2, His (HEK-expressed)
- Recombinant Human Insulin-like growth factor-binding protein 4, His (HEK-expressed)
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