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Recombinant Human Interleukin-12
英文名：
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| 性狀 | Recombinant Human Interleukin-12 (HEK293-expressed) 是一種 HEK293 細(xì)胞來源的促炎細(xì)胞因子。
Synonyms rHuIL-12; NKSF; CTL maturation factor (TCMF); Cytotoxic lymphocyte maturation factor (CLMF) Species Human Source HEK 293 Accession P29459 Gene ID 3592 Molecular Weight Approximately 75 kDa AA Sequence p35 Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLMDPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS p40 Subunit: I Biological Activity The ED50 is <2 ng/mL as measured by NK cells, corresponding to a specific activity of >5 ×105 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Interleukin-12 (HEK293-expressed) (rHuIL-12) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human Interleukin-12 (HEK293-expressed) (rHuIL-12) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Recombinant human IL-12 (hIL-12) is from the serum-free supernatants of stable IL-12-transduced HEK293 cells. Interleukin-12 is a heterodimeric, pro-inflammatory cytokine that is a key driver of cell-mediated immunity. Interleukin-12 (IL-12), previously known as natural killer cell stimulatory factor (NKSF) and cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric cytokine comprised of p40 and p35 subunits linked by an inter-subunit disulfide bridge. Among its many pleiotropic functions, IL-12 has been shown to induce: (i) IFNγ production; (ii) proliferation of activated T and NK cells; and (iii) TH1 differentiation. These functions are mediated by binding of intact IL-12 to its heterodimeric transmembrane receptor complex consisting of two chains, IL-12Rβ1 and IL-12Rβ2[1]. |
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