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DAPK2 (N-term)
英文名：Rabbit Monoclonal IgG
Cas號：
Cas號：
檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308113499-100g | 現貨 | 0 | ￥0 |
| 別 名 | DAP kinase 2, DAP-kinase-related protein 1, DRP-1 |
| Cas號 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 產品參數 | 【產品介紹】Protein kinase termed death-associated
protein kinase 2 (DAPK2) dependant on calcium/ calmodulin (Ca2+/CaM) contains an N-terminal protein kinase domain followed by a conserved CaM-binding domain with significant homologies to those of DAP kinase, a protein kinase involved in apoptosis. Overexpression of DAPK2 significantly induced the m o r phological changes characteristic of apoptosis. Results indicate that DAPK2 is an additional member of DAP kinase family involved in apoptotic signaling (1). The region of homology spans the catalytic domain a n d the CaM-regulat o r y region, whereas the remaining C-terminal part of the protein differs completely from DAP kinase a n d displays no homology to any known protein. The catalytic domain is also homologous to the recently identified ZIP kinase a n d to a lesser extent to the catalytic domains of DRAK1 a n d -2 (2). DAPK2 has a novel regulat o r y mechanism that controls its pro-apoptotic functions. It comprises a single autophosph o r ylation event mapped to Ser308 within the CaM regulat o r y domain. A negative charge at this site reduces both the binding to CaM a n d the f o r mation of DRP-1 homodimers (3). WB: 1:2000 IHC: 1:50 100 Flow Cytometry: 1:15 A. Western blot analysis on rat spleen lysate using anti-DAPK2 RabMAb (cat. # 2009-1), dilution 1:2000. B. Immunohistochemical staining of paraffin-embedded human liver carcinoma using anti-DAPK2 RabMAb (cat. #2009-1). |
| 性狀 | 【反應特異性】Human , Mouse , Rat
【克隆 ID】EP1633Y 【用途】WB , IHC , FC 【抗原分子量】43 kDa |
| 貯存 |
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