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Beclin-1
英文名：Rabbit Monoclonal IgG
Cas號：
Cas號：
檢測信息查詢
| 貨號 | 規(guī)格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308113364-100ul | 現(xiàn)貨 | 0 | ￥0 |
| 別 名 | Coiled-coil myosin-like BCL2-interacting protein, Protein GT197 |
| Cas號 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 產品參數(shù) | 【產品介紹】The Beclin-1 (BECN1) gene encodes a
60-kDa coiled-coil protein that interacts with the prototypic apoptosis inhibit o r Bcl-2 (1). Beclin-1 promotes autophagy in autophagy-defective yeast with a targeted disruption of agp6/vps30, a n d in human MCF7 breast carcinoma cells. The autophagy-promoting activity of Beclin-1 in MCF7 cells is associated with inhibition of MCF7 cellular proliferation, in vitro clonigenicity a n d tum o r igenesis. Endogenous Beclin-1 protein expression is frequently low in human breast epithelial carcinoma cell lines a n d tissue, but is expressed ubiquitously at high levels in n o r mal breast epithelia (2). It has also been shown that Beclin 1 contains a leucine-rich nuclear exp o r t signal motif raising the possibility that its autophagy a n d / o r tum o r suppress o r function may require regulated, CRM1-dependent, nucleocytoplasmic transp o r t (3). WB: 1:5000 IHC: 1:50 ICC: 1:50 100 IP: 1:50 A. Western blot analysis on A431 cell lysate using anti-Beclin-1 RabMAb (cat. # 2026-1), dilution 1:5000. B. Immunohistochemical staining of paraffin-embedded human breast tissue using anti-Beclin-1 RabMAb (cat. #2026-1). |
| 性狀 | 【反應特異性】Human
【克隆 ID】EPR1733Y 【用途】WB , IHC , ICC , IP 【抗原分子量】52 kDa |
| 貯存 |
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