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4E-BP1/2/3 Phospho (pT45) (EIF4EBP1)
英文名：Rabbit Monoclonal Antibody
Cas號(hào)：
Cas號(hào)：
檢測(cè)信息查詢
| 貨號(hào) | 規(guī)格 | 貨期 | 庫(kù)存 | 價(jià)格 | 促銷價(jià) | 訂購(gòu) |
| 1308113298-100ul | 現(xiàn)貨 | 0 | ￥0 |
| 別 名 | EIF4EBP1 antibody, 4E-BP1 antibody, 4EBP1 antibody, BP-1 antibody, MGC4316 antibody, PHAS-I antibody, Eukaryotic translation initiation factor 4E-binding protein 1 antibody, Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody |
| Cas號(hào) | |
| M D L | |
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| 分子量 | |
| 產(chǎn)品參數(shù) | 【產(chǎn)品介紹】4E-BP1 (eIF4E-binding protein) also known
as PHAS, is a 10-12 kDa acidic protein that compete with eIF4G for binding of eiF4E to the mRNA 5 cap structure (1). Binding of the 4E-BPs to eIF4E is reversible and is dependent on the phosphorylation status of 4E-BP. Non-phosphorylated 4E-BP1 will bind strongly to eiF4E while, the phosphorylated form will no (2)t. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating 4E-BP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the 4EBP1-eIF4E interaction (3-4) Recommended Applications WB, IHC, ICC, IP Applications and Recommended Dilution Factors WB: 1:5000 IHC: 1:50 ICC: 1:100 IP: 1:10 Species Reactivity * Human, Mouse *Cross reactivity determined by western blot only. Specificity A phospho specific peptide corresponding to residues surrounding threonine 45 was used as an immunogen. This antibody detects 4E-BP1/2/3 phosphorylated at threonine 45. |
| 性狀 | 【反應(yīng)特異性】Human , Mouse
【克隆 ID】EPR2169Y 【用途】WB , IHC , ICC , IP 【抗原分子量】15 - 20kDa |
| 貯存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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